Cornell Research feature on Robert S. Langer ’70 Family and Friends Professor Shaoyi Zhang's research on zwitterionic materials. Read more about Protective Materials that Mimic Water
Shaoyi Jiang joined the Meinig School as Robert S. Langer ’70 Family and Friends Professor in June 2020. Prior to Cornell he was the Boeing-Roundhill Professor of Engineering in the Department of Chemical Engineering and an adjunct professor of Bioengineering at the University of Washington, Seattle.
Jiang’s research focuses on the molecular understanding, design and development of functional zwitterionic materials for biomedical and engineering applications. Since the early 2000s, his group has proposed the concept of super-hydrophilic zwitterionic materials, provided a molecular-level understanding of non-fouling mechanisms and developed several new classes of zwitterionic materials, including poly(carboxybetaine), poly(sulfobetaine), poly(trimethylamine N-oxide), poly(zwitterionic phosphatidylserine), and glutamic acid (E) and lysine (K)-containing poly(peptides). While the super-hydrophilic properties of zwitterionic materials are responsible for their excellent biocompatibility, the amphiphilic properties of their poly(ethylene glycol) (PEG) counterparts are the origin of their immunogenicity. His group has demonstrated no capsule formation upon subcutaneous implantation in mice for one year, expansion of hematopoietic stem and progenitor cells (HSPCs) without differentiation, no anti-coagulants needed for artificial lungs in sheep, no antibodies generated against zwitterionic polymers and long-lasting marine coatings.
At Cornell, his group aims to (a) integrate immunology into existing biomaterials research programs to develop immune-modulating biomaterials, assisted by a fundamental understanding at the molecular and cellular levels and artificial intelligence-directed materials discovery; (b) translate his biomaterials technologies into medical and engineering practice in nanomedicine/drug delivery/ cancer immune therapeutics, regenerative medicine/tissue engineering/stem cells, medical devices and marine coatings. His group has close collaborations with researchers at Weill Cornell Medicine, Memorial Sloan Kettering, Cornell College of Veterinary Medicine, Cornell Center for Immunology and several academic departments at Cornell.
Jiang's lab currently has multiple postdoctoral positions available.
A virtual field trip of the Jiang Lab for 3rd-4th graders by Erica Wagner.
- Biomedical Engineering
- Biomolecular Engineering
- Colloids and Interfacial Science
- Drug Delivery and Nanomedicine
- Materials Design
- Materials Synthesis and Processing
- Molecular and Cellular Engineering
- Molecular Biotechnology
- Nanobio Applications
- Polymers and Soft Matter
- Statistical Mechanics and Molecular Simulation
- Tissue Engineering and Biomaterials
- Drug Delivery and Nanomedicine
- Biomolecular Thermodynamics
- Introduction to Molecular Modeling and Simulation Methods
- T. Bai, J. Li, S. Imren, A. Sinclair, F. Merriam, F. Sun, M. O'Kelly, C. Nourigat, P. Jain, J. J. Delrow, R. S. Basom, H.-C. Hung, P. Zhang, B. Li, S. Heimfeld, S. Jiang, C. Delaney. 2019. "Culture in Zwitterionic Hydrogels Promotes Expansion of Human Hematopoietic Stem Cells." Nature Medicine. 25, 1566.
- P. Zhang, E.J. Liu, C. Tsao, S.A. Kasten, M. V. Boeri, T. L. Dao, S. J. DeBus, C. Linn Cadieux, T.C. Otto, D. M. Cerasoli, Y. Chen, P. Jain, F. Sun, W. Li, H-C. Hung, Z. Yuan, J. Ma, N. Bigley, F M. Raushel and S Jiang. 2019. "Nanoscavenger Provides Long-term Prophylactic Protection against Nerve Agents." Science Translational Medicine 11 (473), aau7091.
- P. Zhang, F, Sun, C. Tsao, S. Liu, P. Jain, H.C. Hung, T. Bai, K. Wu and S. Jiang. 2015. "Zwitterionic encapsulation promotes protein stability, enhances pharmacokinetics and reduce immune response." Proceedings of the National Academy of Sciences, 112, 12046.
- L. Zhang, Z. Cao, L. Carr, T. Bai, J.R. Ella-Menye, C. Irvin, B.D. Ratner and S. Jiang. 2013. "Zwitterionic Hydrogels Implanted in Mice Resist the Foreign-body Reaction." Nature Biotechnology, 31, 553. Selected by one of eight “major hits” in 20 years of Nature Biotechnology medical research, Nature Biotechnology, 34, 262 (2016).
- A. Keefe and S. Jiang. 2012. "Poly(zwitterionic)protein Conjugates Offer Increased Stability without Sacrificing Binding Affinity or Bioactivity." Nature Chemistry 4 59-63.
Selected Awards and Honors
- Associate Editor, Science Advances, American Association for the Advancement of Science, October 2018
- Braskem Award for Excellence in Materials Engineering and Science, 2017.
- Fellow, American Institute of Chemical Engineers, 2012 –
- Senior Editor, Langmuir, American Chemical Society, 2010-
- Fellow, American Institute of Medical and Biological Engineering, 2010-
B.S. (Chemical Engineering), Hua Qiao University, 1985
M.S. (Chemical Engineering) Nanjing Institute of Chemical Technology, 1988
Ph.D. (Chemical Engineering), Cornell University, 1993
Postdoctoral Fellow (Chemistry), University of California at Berkeley, 1993-1994
Research Fellow (Chemistry), California Institute of Technology, 1994-1996