Iwijn De Vlaminck
We are a biomedical and single-cell genomics lab in the biomedical engineering department of Cornell: our research brings approaches from biophysics and genomics to biomedicine. We pursue novel measurement principles in cell-free DNA diagnostics and single-cell biology.
Cell-free DNA: When cells turn over in body tissue, their genomes persist for some time in circulation in the form of cell-free DNA. Cell-free DNA is abundantly present in plasma and provides an information-rich window into human physiology, with rapidly expanding applications in cancer diagnosis and treatment monitoring, prenatal diagnosis, and monitoring of rejection in transplantation. The lab develops assays to interrogate cell-free DNA via sequencing, with an eye on improved accuracy, lower cost and blood volume requirements, and new applications in clinical diagnostics.
Single-cell genomics: Advances in DNA sequencing and microfluidics now make it possible to perform sequence analyses of the genomes and the gene expression programs of single cells. The lab has an interest in the development and application of sensitive single-cell genome sequencing principles, in particular measurements that retain information about temporal dynamics and spatial context, and combinations of single cell genome sequencing with microscopy techniques. Applications of single cell sequencing are found in human biology and microbiology.
- 2013. "Temporal response of the human virome in responseto immune modulation and antiviral therapy." Cell 155 (1178): 1178-1187. .
- 2014. "Circulating Cell-Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection." Science Transitional Medicine 6 (241): 241ra77. .
- 2012. "Mechanism of homology recognition in DNA recombination from dual-molecule experiments." Molecular cell 46 (616): 616-24. .
- 2015. "Non-invasive monitoring of infection and rejection after lung transplantation." Proceedings of the National Academy of Sciences 112 (43): 13336-13341. .
- 2015. "Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma." Scientific Reports. .
Selected Awards and Honors
- Robert N. Noyce Assistant Professorship in Life Science and Technology 2015
- IWT Fellowship (Agency for Innovation by Science and Technology (IWT)) 2003
- BOFZAP Research Professorship (K.U. Leuven, Belgium) 2014
- Student Publications Award (IMEC Leuven) 2008
- BS (Electronic Engineering), K.U. Leuven, 2000
- MS (Electronic Engineering), K.U. Leuven, 2003
- Ph D (Science and Engineering), K.U. Leuven, 2008