BME7900 Seminar Series - Shuibing Chen, PhD



Weill Hall 226


We welcome our first speaker of the Spring semester, Dr. Shuibing Chen. Dr. Chen is the Kilts Family Professor in the Department of Surgery at Weill Cornell Medicine. She is also applying for field membership in the Meinig School of Biomedical Engineering.

Human Pluripotent Stem Cells, Organoids, and Precision Medicine

Abstract: The major research interest of our Laboratory is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research. Our current main focus is on human pluripotent stem cells (PSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). We combine our knowledge of stem cell biology, developmental biology, chemical biology, medicine chemistry and tissue engineering to derive functional cells, tissues and organs from human pluripotent stem cells. Our long-term goal is to apply patient specific PSC-derived tissues or organs for replacement therapy and build up “disease in a dish” platforms for drug discovery.

Bio: Dr. Shuibing Chen is the Kilts Family Professor, Vice Chair of Innovation, and the Director of the Diabetes Program in the Department of Surgery, and the Director of the Center of Genomic Health at Weill Cornell Medicine. She received my B.S. and M.S. in Chemistry from Tsinghua University in China. Then, she pursued my PhD under the advisement of Dr. Peter G. Schultz at the Scripps Research Institute. After graduation, she joined Dr. Doug Melton’s laboratory at Harvard University.

The major research interest in the Chen Laboratory focuses on human pluripotent stem cell-derived organoids for disease modeling and drug screening. In response to the COVID-19 pandemic, Dr. Chen created a panel of human pluripotent stem cell-derived cells/organoids to study SARS-CoV-2 infection. Part of these work has been published on Nature, Cell Stem Cells, Cell Metabolism, Circulation Research, etc. Dr. Chen serves on the editorial board of Cell Stem Cell, Stem Cell Reports, Journal of Molecular Cell Biology, et al. She also serves as the Chair of the Scientific Program Committee of International Chemical Biology Society. She has received many awards including New York Stem Cell Foundation Robertson Investigator, American Diabetes Association (ADA) Innovative Award, NIH Director’s New Innovator Award, and ISSCR Dr. Susan Lim Award for Outstanding Young Investigator, etc.