Prior to joining the Cornell faculty Claudia Fischbach-Teschl conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences. She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany, and holds an M.S. in Pharmacy from Ludwigs-Maximilians-University, Munich, Germany.
Microenvironmental conditions are critically important in tumor induction and progression, and mediate the establishment of metastases at preferential target sites. By exploring diversified tissue-engineered model systems, microfabrication strategies, and polymeric growth factor delivery strategies, the research of our lab aims at elucidating microenvironmental events that currently impair the prognosis of cancer patients and to develop new drug delivery systems for more effective treatment of cancer. To this end, we focus on three main areas of interest: (1) To assess the role of structural and biomechanical characteristics of the extracellular matrix in regulating primary and metastatic breast cancer, (2) to investigate brain tumorigenesis as a function of cell-cell communication between brain tumor stem cells and endothelial cells in the perivascular niche, and (3) to analyze chemical and physical microenvironmental conditions underlying tumor angiogenesis using microfabricated hydrogel scaffolds. This research contributes to a better understanding of the complex signaling networks underlying tumor malignancy and culminate in the identification of therapeutic targets and drug delivery technologies that may fundamentally change the way tumors are treated in the future.
- 2011. "Hydroxyapatite Nanoparticle-containing scaffolds for study of breast cancer bone metastasis." Biomaterials 32 (22): 5112-5122. .
- 2010. "Oxygen-controlled 3-D cultures to analyze tumor angiogenesis." Tissue Engineering Part A 16 (7): 2157-2159. .
- 2009. "Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement." PNAS 106 (2): 399-404. .
- 2007. "Engineering tumors with 3D scaffolds." Nat Methods 4 (10): 855-60. .
- 2013. "Engineered Culture Models for Studies of Tumor-Microenvironment Interactions." Annual Review of Biomedical Engineering 15: 29-53. .
Selected Awards and Honors
- Affinito Stewart Award (The President's Council of Cornell Women) 2010
- ORS Young Investigator (AAOS / ORS Molecular Biology and Therapeutics in Musculoskeletal Oncology (MBTMO) Meeting) 2008
- Award for Outstanding Dissertations (Eastern Bavarian Universities) 2004
- Poster Award by the Department of Health and Human Services (Keystone Symposia 'Molecular Control of Adipogenesis and Obesity') 2004
- Postdoctoral Research Fellowship (German National Science Foundation) 2003
- MS (Pharmacy), Ludwig Maximilians University, 1998
- Ph D (Pharmaceutical Technology), University of Regensburg, 2003