BME7900 Seminar - Jude Phillip, PhD

to

Location

Weill Hall 226

Description

We welcome Dr. Jude Phillip as the next speaker in our series. Dr. Phillip is from Johns Hopkins University, where he is an Assistant Professor in Biomedical Engineering. Ageing at Cell Resolution ABSTRACT: The process of ageing is inevitable, and while we gain one chronological year with the passing of each birthday, the biological outlook among individuals is quite variable. A growing body of evidence shows that the interactions of intrinsic and extrinsic factors, across length scales from molecules to organisms, contribute to the rates of ageing and age-related diseases in humans. However, it is unclear how the underlying molecular states of an individual relate to their clinical outlook. We postulate that studying age-associated changes at the intermediate length scale of cells–between the larger length scale of organs and tissues and the smaller length scales of molecules–may provide a key link to understanding the inter-relation among ageing scales. As integrators of molecular signals, cells offer a sensitive meso-scale view of ageing and disease, with cellular dysfunctions likely occurring prior to the manifestation of diseases at the clinical level. In addition, populations of cells typically display dynamic and heterogeneous phenotypes. Recently, we have shown that ageing information in encoded in the biophysical properties of cells, such as cell morphology and cell motility. In my seminar, I will present data on: 1) how single-cell motility patterns constitute a robust cell-based biomarker of ageing, 2) the role of phenotypic heterogeneity in propagating this ageing information, and 3) a generalizable framework to understand emergent patterns of single-cell motility with applications to health and disease. BIO: Dr. Jude M. Phillip is an Assistant Professor of Biomedical Engineering, with secondary appointments in the departments of Chemical & Biomolecular Engineering, Oncology and is a Core Member in the Institute for Nanobiotechnology (INBT) at Johns Hopkins University. He completed his B.Eng. degree at the City College of New York in Chemical Engineering, and a PhD. in Chemical and Biomolecular Engineering at Johns Hopkins University under the mentorship of Dr. Denis Wirtz. He then completed his postdoctoral training at Weill Cornell Medicine with Drs. Leandro Cerchietti and Ari Melnick with a focus on hematological malignancies and the lymphoma microenvironment. At Johns Hopkins his lab studies biological ageing dynamics in the context of health and disease. He combines fundamental engineering approaches with translational ageing and oncology research to develop strategies and technologies to probe ageing and disease, with the goal of identifying translatable mechanisms to modify ageing trajectories to drive heath.