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Molecular & Cellular Engineering

Cornell biomedical engineers implement multidisciplinary and multi-scale strategies that combine advanced high resolution imaging, biophysics, microfabrication, genetic modifications, protein engineering, and quantitative modeling to analyze and manipulate cell and molecular dynamics and interactions. We are motivated by the goal of uncovering the details of normal cell functions and disease processes, improve diagnostics, and develop novel therapeutic approaches. Cornell’s world-class expertise and resources that include the Cornell NanoScale Science & Technology Facility (CNF), the Nanobiotechnology Center, the Biotechnology Resource Center, the Cornell Physical Science Oncology Center, and Cornell’s top-ranked veterinary school and medical school synergize to create an ideal environment for research in Molecular and Cellular Engineering.

Some specific faculty projects:

Prof. Jonathan Butcher’s group studies how microenvironmental cues govern the transdifferentiation of heart valve cells towards osteogenic lineages, and identify principle mechanobiological pathways to target for molecular therapies to delay or rescue valve calcification. The Butcher lab also investigates the molecular regulation of embryonic valvular progenitor maturation and uses this program to engineer autologous valvular phenotypes for regenerative medicine applications.

Prof. Ben Cosgrove’s lab studies how muscle stem cells interpret and process microenvironmental information through signaling networks that govern their cell fate during tissue maintenance and repair. Inspired by these regulatory insights, his lab engineers molecular features into self-assembled and micro-fabricated 3D biomaterials to enhance stem cell contributions to muscle regeneration.

Prof. Claudia Fischbach-Teschl’s lab studies the role of cell-microenvironment interactions in the development, progression, and therapy resistance of cancer. In particular, her group integrates microfabrication and tissue engineering strategies to test the impact of extracellular matrix composition, structure, and mechanical properties on tumor angiogenesis, stroma remodeling, and bone metastasis.

Prof. Christopher Hernandez’s lab studies the effects of mechanical forces on prokaryotic organisms including bacteria to examine bacterial growth and resistance to antibiotics. His research team using novel micro/nanofluidic devices, super-resolution microscopy and mechanical modeling.

Prof. Jan Lammerding’s laboratory is using a combination of microfabrication, time-lapse microscopy, and stem cell biology to create in vitro models of skeletal and cardiac muscle to study how mutations in nuclear envelope proteins cause muscular dystrophies and heart disease, and how cells translate mechanical stimuli into biochemical signals. In addition, the Lammerding lab is applying cell and molecular engineering approaches to investigate how changes in nuclear structure and mechanics can modulate cell migration in 3-D environments and facilitate cancer metastasis.

Research Area Faculty

  Name Department Contact
caa238.jpg Alabi, Christopher A.
Assistant Professor and Nancy and Peter Meinig Family Investigator in the Life Sciences
Chemical and Biomolecular Engineering 356 Olin Hall
607 255-7889
ilb8.jpg Brito, Ilana Lauren
Assistant Professor, Mong Family Sesquicentennial Faculty Fellow in Biomedical Engineering
Biomedical Engineering 289 Kimball Hall
607 254-2938
jtb47.jpg Butcher, Jonathan T.
Associate Professor, Associate Director of BME, Director of Undergraduate Studies
Biomedical Engineering 304 Weill Hall
607 255-3575
bdc68.jpg Cosgrove, Benjamin David
Assistant Professor
Biomedical Engineering 159 Weill Hall
607 255-7271
id93.jpg De Vlaminck, Iwijn
Robert N. Noyce Assistant Professor in Life Science and Technology
Biomedical Engineering 301 Weill Hall
md255.jpg DeLisa, Matthew P.
William L. Lewis Professor of Engineering
Chemical and Biomolecular Engineering 254 Olin Hall
607 254-8560
de54.jpg Erickson, David Carl
Sibley College Professor of Mechanical Engineering
Mechanical and Aerospace Engineering 369 Upson Hall
607 255-4861
cf99.jpg Fischbach-Teschl, Claudia
Associate Professor
Biomedical Engineering 157 Weill Hall
607 255-4547
tk499_eng.jpg Kawate, Toshi
Assistant Professor
Biomedical Sciences, Vet Med C4-151 Veterinary Medical Center
bk88.jpg Kirby, Brian J.
Professor
Mechanical and Aerospace Engineering 377 Kimball Hall
jl2792.jpg Lammerding, Jan
Associate Professor, Director of Graduate Studies
Biomedical Engineering 235 Weill Hall
607 255-1700
jtl10_eng.jpg Lis, John
Professor
Molecular Biology and Genetics
dl79_eng.jpg Luo, Dan
Professor
Biological and Environmental Engineering
cko3.jpg Ober, Christopher Kemper
Francis Norwood Bard Professor of Materials Engineering
Materials Science and Engineering Room 310 Bard Hall
607 255-8417
mjp31.jpg Paszek, Matthew J.
Assistant Professor
Chemical and Biomolecular Engineering 360 Olin Hall
607 255-6277
lp26.jpg Pollack, Lois
Professor and Director
Applied and Engineering Physics 254 Clark Hall
607 255-8695
as2833.jpg Singh, Ankur
Assistant Professor
Mechanical and Aerospace Engineering, Biomedical Engineering 389 Kimball Hall
607 255-2194
mw272_eng.jpg Wu, Mingming
Associate Professor
Biological and Environmental Engineering