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Postdoctoral Researchers: Schaffer-Nishimura Lab

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Multiple positions for postdoctoral researchers in the Schaffer-Nishimura Lab.

In the Schaffer-Nishimura Lab (, we take a multidisciplinary approach to studying the in vivo cellular behaviors that underlie health and disease. We develop optics-based tools and techniques to enable detailed studies of cellular motion, interactions, and function, all in living animals. These approaches enable us to study the cellular behaviors that drive normal and disease physiology in ways not previously possible, with major research projects in neuroscience and the neurobiology of disease, cardiovascular disease, and stem cell biology.

We have openings for talented post-doctoral researchers in several projects:

  • Advancing the use of three-photon microscopy for imaging neural activity in the brain and spinal cord of mice and using this approach to elucidate the neural activity patterns that encode limb motion while walking over simple and complex terrain.
  • Developing optical methods to record activity from large ensembles of individual neurons using spectral information from multiple variants of genetically encoded voltage and calcium indicators, with applications in both neuroscience research and neuroprosthetics.
  • Understanding age-related deficits in how the stem cell niche recovers from damage using time-lapse, in vivo, multiphoton microscopy of intestinal crypts through abdominal windows in mice.
  • Using in vivo imaging to study the causes and consequences of microvascular blood flow disruptions in animal models of neurodegenerative disease, with the goal of identifying novel therapeutic approaches.

The SN Lab fosters a highly interdisciplinary and diverse research environment, with current lab members coming from six continents and having research backgrounds that include physics, engineering, computer science, neuroscience, physiology, and medicine. We encourage applications from researchers with physics, engineering, or other quantitative backgrounds who are interested in learning to apply their skills to biological problems, as well as from researchers with a life science or biomedical research background who are interested in learning to use state-of-the-art optical approaches to elucidate cellular behaviors. Candidates must have completed a PhD in a relevant field by the start date. Positions are available now, but we will have some flexibility for start dates. Interested candidates should send a cover letter and CV to Nozomi Nishimura ( and Chris Schaffer ( The most promising candidates will be invited for an on-site interview.