Researchers propose mechanism for spread of metastatic breast cancer to bone
Meinig School Assoc. Prof. Claudia Fischbach is a co-author on an article that reports research using a mineral-containing 3D scaffold as an in vitro model to study whether factors such as breast tumor-derived compounds and mechanical stimulation within the bone microenvironment affect the interactions between metastatic cancer cells and bone. Understanding and intervening in these interactions could have clinical implications for the nearly 75% of patients with advanced breast cancer in whom incurable skeletal metastatic disease develops.
The article, entitled "Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals" was published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers in November.