Professor Michael Shuler receives Lush Science Prize
Congratulations to Professor Michael Shuler on winning a 2015 Lush Science Prize, an award that recognizes projects and individuals who work towards replacing animals in toxicity testing. Dr. Shuler received the prize in London, and is pictured with it on the Lush Prize website.
Michael Shuler is the Samuel B. Eckert Professor of Engineering. He was the Director for the School of Chemical Engineering from 1998 to 2002 and the founding chair for Biomedical Engineering (2004 - present), where until last year he was he was the James and Marsha McCormick Chair.
Dr. Shuler’s research focuses on applying chemical reaction engineering principles to biological systems. His group has developed a new approach to model individual cells mathematically. These models have proven to be important conceptual tools used to test hypotheses about cellular mechanisms. Another project combines mathematical models of subcellular and cellular mechanisms with whole-animal models as a means to relate the rapidly increasing insight into molecular toxicology and pharmacology with animal physiology. The organs of mathematical models are compared with physical models that use living cells to mimic organs such as the liver, colon, GI tract and lung. These devices are constructed on a microscale using the techniques of nanotechnology and are known as "Body-on-a-Chip" devices.
Dr. Shuler's work is being applied to evaluate different treatments for cancer such as multi-drug resistant cancer. He is also constructing models of the microvasculature to understand better how cancer cells metastasize. He is also investigating controlled drug delivery to brain tumors.
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