Moonsoo Jin received an undergraduate degree from Seoul National University, Seoul, Korea and both of his master and doctoral degrees at MIT. Then he moved to Harvard Medical School for his postdoctoral training in what can be broadly defined as protein engineering and design. In 2006, he joined Cornell University as a faculty in the department of Biomedical Engineering. His lab uses multi-scale, interdisciplinary approaches to developing proteins for therapy and diagnosis applications. He received New Investigator Recognition Award by Orthopaedic Research Society (2003), Scientist Development Grant from the American Heart Association (2008), and NIH Transformative R01 Grants (2009).
We are studying protein-protein interactions that occur at virus entry into host cells and escape from endosome into cytosol, between cellular adhesion molecules in the immune system, and tumor development. Through this understanding, we are particularly interested in developing therapeutic molecules in passive immunotherapy to treat infectious diseases, drugs that would inhibit aberrant infiltration of immune cells in autoimmunity, and nanoparticles that would detect and kill tumors in the body. We utilize diverse molecular biology, biochemistry, and biophysical tools and develop unique protein engineering platforms implemented by directed evolution and rational design. Some of the novel proteins are being utilized for detection of diseased cells and tissues by whole body optical imaging, MRI, CT, and PET.
- 2014. "Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface." PLoS One 9 (3). .