People

George K Lewis Jr.

MS/PhD Graduate Student

We are researching and developing portable and powerful ultrasound systems for therapeuticmedicine. We have developed the first and currently only, ultralow output impedance amplifier technology that is 95-99% efficient at delivering electrical energy to be converted into acoustic power. Currently, we are developing these systems for various industry and academic collaborations.

In our own lab, we are using this technology to drive pharmaceuticals into human brain tissue in a targeted manor. The overall goal is to deliver the drug into the neurological tissue where the physician wants it to be delivered, so it may be as effective as possible.

We are also interested in developing 1-2mm acoustic catheters and probes that may be implanted or guided to the brain, where they could apply therapeutic acoustic power (e.g. ablation, warming, drug-delivery, or other possible applications) applications in human/animal.

Our lab is also developing disposable fetal monitoring transducers that sense the fetal heart rate and uterin contraction is a single 1 inch diameter device. The technology is wireless and attaches to current fetal monitoring devices.

Finally, our lab has developed a low-cost electrical impedance analyzer for various impedance spectroscopic applications for ultrasonics, biology and other applications.

Biographical Sketch of George Lewis

Research on the evening news 2009 

Research images

Selected Publications

1. "A portable high intensity focused ultrasound device for the non invasive treatment of varicose veins" G. Lewis Jr. et al. In Preparation 2009
2. "Rapid broad-band impedance spectroscopy measurement approach for piezo-materials and ultrasound" G.Lewis Jr. et al., J. MST, AIP (2008)
3. "Low-Cost Efficient High Power 0-10MHz Ultrasound Driver Design with PCB Schematic and Analysis of Ultrasound Power Production Performance" G. Lewis Jr. et al. In Preparation 2009
4. "Portable HIFU system for military, medical and research use" G.Lewis Jr. Am. Ist. Phys., Rev. Sci. Inst., (2008)
5. "Ultrasound enhanced drug delivery to soft animal tissues" Proc. Int. Syp. Ther. Ultas., (2008)
6. "Acoustic enhanced evans blue dye perfusion in neurological tissues" G.Lewis Jr. et al., J. Acoust. Soc. Am. 122, 3007 (2007)"
7. "Acoustic chemotherapy delivery to combat brain cancer" G.Lewis, ASA Meeting Press Release 2007
8. "A phantom feasibility study of acoustic enhanced drug delivery" G. Lewis and W. Olbricht, IEEE, November 2007
9. Effects of background fluorescence in fluorescence molecular tomography GK Lewis et al, Applied Optics, 2005 - OSA
10. Lab research in the news 2007
11. Lab research in the news 2008

Podium Presentations

1. Development of a Portable Therapeutic and Surgical Ultrasound System for Military and Medical Use, ASA, November 2008, Miami, FL
2. Portable Theraputic Ultrasound Device, BMES, October 2008, St. Louis, MO
3. Acoustic Drug Delivery to Soft Animal Tissues, ISTU, September 2008, Minnisota
4. Acoustic Enhanced Drug Delivery, BMES, September 2007, California
5. Acoustic Enhanced Perfusion in Neurological Tissue, IEEE/NIH, November 2007, Maryland
6. Acoustic Enhanced Perfusion in Neurological Tissue, ASA, November 2007 New Orleans,

Education

• National Science Foundation Fellow 2007-2010
• Presidential Life Science Fellow 2006-2007
• M.S. , 2008- Cornell University, Biomedical Drug Delivery and Device Development
• BS summa cum laude, 2006 - University of Miami, Biomedical Mechanical Engineering

Special Committee

• Chair: William Olbricht
• Ronald Booker
• Lawrence Bonassar